Characterization and prediction of clinical pathways of vulnerability to psychosis through graph signal processing

C Sandini; D Zöller; M Schneider; A Tarun; M Armondo; B Nelson; PG Amminger; HP Yuen; C Markulev; MR Schäffer; N Mossaheb; M Schlögelhofer; S Smesny; IB Hickie; GE Berger; EY Chen; L De Haan; DH Nieman; M Nordentoft; A Riecher-Rössler; S Verma; A Thompson; AR Yung; PD McGorry; D van de Ville; S Eliez

Journal article

Characterization and prediction of clinical pathways of vulnerability to psychosis through graph signal processing

C Sandini, D Zöller, M Schneider, A Tarun, M Armondo, B Nelson, PG Amminger, HP Yuen, C Markulev, MR Schäffer, N Mossaheb, M Schlögelhofer, S Smesny, IB Hickie, GE Berger, EY Chen, L De Haan, DH Nieman, M Nordentoft, A Riecher-Rössler Show all

Elife | eLIFE SCIENCES PUBL LTD | Published : 2021

DOI: 10.7554/eLife.59811

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Abstract

There is a growing recognition that psychiatric symptoms have the potential to causally interact with one another. Particularly in the earliest stages of psychopathology dynamic interactions between symptoms could contribute heterogeneous and cross-diagnostic clinical evolutions. Current clinical approaches attempt to merge clinical manifestations that co-occur across subjects and could therefore significantly hinder our understanding of clinical pathways connecting individual symptoms. Network approaches have the potential to shed light on the complex dynamics of early psychopathology. In the present manuscript we attempt to address 2 main limitations that have in our opinion hindered the a..

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University of Melbourne Researchers

Barnaby Nelson Author

Paul Amminger Author

Hok Yuen Author

Connie Markulev Author

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Awarded by Stanley Medical Research Institute

Funding Acknowledgements

[ "Stanley Medical Research Institute 07TGF-1102 Barnaby Nelson Paul G Amminger Hok Pan Yuen Connie Markulev Monica R Scha ffer Nilufar Mossaheb Monika Schlo gelhofer Stefan Smesny Ian B Hickie Gregor Emanuel Berger Eric YH Chen Lieuwe de Haan Dorien H Nieman Merete Nordentoft Anita Riecher-Rossler Swapna Verma Andrew Thompson Alison Ruth Yung Patrick D McGorry", "National Health and Medical Research Council 566529 Ian B Hickie Alison Ruth Yung", "National Health and Medical Research Council 1060996 Patrick D McGorry", "National Health and Medical Research Council 1080963 Alison Ruth Yung Patrick D McGorry", "National Health and Medical Research Council 566593 Alison Ruth Yung Patrick D McGorry", "National Health and Medical Research Council 1027532 Barnaby Nelson", "Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung FNS 320030_179404 Stephan Eliez", "Schweizerischer Nationalfonds zur Fo rderung der Wissenschaftlichen Forschung FNS 324730_144260 Stephan Eliez", "Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung PZ00P1_174206 Maude", "Schneider Schweizerischer Nationalfonds zur Fo rderung der Wissenschaftlichen Forschung 51NF40-158776 Stephan Eliez", "The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication." ]